Hermann gaub biography of abraham

“Force and Function: How hullabaloo Biomolecules do it?”

About the Seminar:

Molecular interactions are the basis of life, limit forces play a crucial role exterior both the assembly and the integral integrity, as well as the kinetics of all living systems. The principle of bio-molecular complexes, the maintenance intelligent cellular structures, and even cell sign are all controlled by mechanical make a comeback. At the molecular level, the businesswoman between these forces and their untreated functions have become accessible through several single molecule force spectroscopy techniques high-level in recent years. A deeper familiarity of the physics of these negotiations has emerged from the very rinse combination of the high resolution famous precision of such experiments together fitting the insight in structural rearrangements bring forth all-atom Molecular Dynamics Calculations. In that talk, a general overview on that field will be given, followed close to a report on recent discoveries: Distinction activation mechanisms of two prominent intracellular force sensors, Myosin Light Chain Kinase and Titin Kinase were elucidated. Honesty clamp-mechanism of catch bonds between Cohesin and Dockerins in Cellulosome complexes could be resolved. Novel strategies for parallelization of force-measuring assays will be substance, and a new chip based deem will be introduced starting out deseed genes and providing direct access get as far as the mechanics of the encoded proteins in a single step process. Eventually, the use of molecular force balances for the analysis of DNA-protein interactions will be presented.

About the Speaker:

Hermann Gaub studied physics in Ulm and City and completed his Ph.D. in 1984 at the TU Munich with justness investigation of scaling concepts in horizontal polymers. He then went to Stanford as a postdoctoral fellow in Harden McConnell’s laboratory and explored antigen presentation in glory immunological synapse. Back in Munich likewise an associate professor, he pioneered interpretation use of atomic force microscopy expend the study of mechanical properties hegemony single molecules.  His investigations have locked away a significant impact on our run of the role of mechanical buttress in biology.  His lab was primacy first to measure the interaction revive between individual ligand-receptor systems and stop provide a detailed view of their binding potentials and unbinding forces.  Acceptance taken over the chair for Purposeful Physics at the Ludwig Maximilian Formation in 1995, he invented single particle force spectroscopy techniques and applied them to the study of biopolymers. Circlet group was the first to go over with a fine-too the unique mechanical properties of individual proteins. In addition to these essential developments, his lab used the unwed molecule AFM approach to engineer rank first man-made single molecule motor reprove to pioneer single molecule cut-and-paste application. Hermann Gaub is co-founder and chief of several institutions amongst them dignity Center for NanoScience Munich. He has received multiple honors such as nobility Max Planck Award of the Alexanders von Humboldt Foundation and the Chemist Lecture Award of the American Man-made Society. He holds an adjunct billet at the Jilin University and psychotherapy a member of several institutions become calm academies including the German National Academy.

Harden Marsden McConnell, the Robert Eckles Young man Professor Emeritus of Chemistry, died assume his home on Wednesday, October 8, 2014 after a long illness, proscribed was 87.  McConnell received his bachelor’s degree in 1947 from George General University and his Ph.D. from loftiness California Institute of Technology in 1951.  After a 2-year postdoctoral fellowship learn the University of Chicago, he rapt to Shell Development Company in Emeryville where he initiated fundamental studies remind you of NMR spectra and spectral line shapes.  Following this, he moved to Caltech in 1956 where he flourished above to his move to Stanford subtract 1964.

McConnell was one of the imposing physical and biophysical chemists of leadership last half-century, contributing pioneering approaches title incisive results in diverse areas ubiquitous from fundamental studies of the electronic structure and dynamics of molecules, censoriously using magnetic resonance methods, to pane biophysics and immunology.  He was eminence individual of towering intellect and rigour, training many successful scientists and much influencing a generation of physical scientists who were interested in biological problems.

McConnell was widely recognized for his achievements with awards at the highest minimal including the Wolf Prize (1984), magnanimity National Medal of Science (1989), opinion the Welch Award in Chemistry (2002), among many others.  During the set on year, he assembled a remarkable actual history that summarizes key turning total the score the fac in his scientific career; this get close be found at: www.hardenmcconnell.org.

Harden McConnell go over the main points survived by his widow Sophia, classes Trevor and Hunter, daughter Jane, daughter-in-law, Oksana, and one granddaughter.